Inflammatory bowel disease (IBD) remains intriguing and challenging for a pediatrician and the causes remain elusive. Past decades have shown an increasing trend in the number of children diagnosed with IBD, and the treatment modalities and diagnostic aids have advanced significantly with increasing awareness and growing scientific evidence. Treatment has evolved from steroids to biologicals, and a majority of children have been managed aggressively with medical treatment solely. The Indian subcontinent has seen an increasing number of children with IBD, as reported by data from various centers, which is very challenging for clinicians and has led to better sensitization of this conundrum in pediatric practice. This review article aims to offer better clarity and to enrich the knowledge of clinicians who either want to know about the multifaceted presentations of pediatric Crohn's disease (CD) or the complexity involving the management of pediatric Crohn's disease has intestinal and extraintestinal manifestations and literally can involve anywhere from mouth to anus. This review aims to cover extensively from the incidence to the complications of Crohn's disease and the newer evolutions in the treatment.
Kapoor A, Bhatia V, Sibal A. Pediatric inflammatory bowel disease. Indian Pediatr 2016;53(11):993–1002. DOI: 10.1007/s13312-016-0975-0
Sathiyasekaran M, Raju BB, Shivbalan S, et al. Pediatric Crohn's disease in South India. Indian Pediatr 2005;42(5):459–463. DOI: 10.3748/wjg.v22.i36.8123
Avinash B, Dutta AK, Chacko A. Pediatric inflammatory bowel disease in South India. Indian Pediatr 2009;46(7):639–640. PMID: 19638665.
Poddar U, Yachha SK, Srivastava A, et al. Pediatric inflammatory bowel disease: is it really uncommon in Asian children? JGH Open 2020;4(5):860–866. DOI: 10.1002/jgh3.12330
Srivastava A, Sathiyasekharan M, Jagadisan B, et al. Paediatric inflammatory bowel disease in India: a prospective multicentre study. Eur J Gastroenterol Hepatol 2020;32(10):1305–1311. DOI: 10.1097/MEG.0000000000001859
Poddar U, Yachha SK, Srivastava A. Pediatric inflammatory bowel disease (P-IBD) in India: is it really uncommon? Am J Gastroenterol 2018 Oct;113:S599-S600 AB 1045
Heyman MB, Kirschner BS, Gold BD, et al. Children with early-onset inflammatory bowel disease (IBD): analysis of a pediatric IBD consortium registry. J Pediatr 2005;146(1):35–40. DOI: 10.1016/j.jpeds.2004.08.043
Sridhar M, Kesavelu D. Fecal calprotectin as a screening marker for inflammatory bowel disease. Indian Pediatr 2019;56(3):249–250.
Ruemmele FM, Veres G, Kolho KL, et al. Consensus guidelines of ECCO/ESPGHAN on the medical management of pediatric Crohn's disease. J Crohns Colitis 2014;8(10):1179–1207. DOI: 10.1016/j.crohns.2014.04.005
Solem CA, Loftus EV Jr, Fletcher JG, et al. Small-bowel imaging in Crohn's disease: a prospective, blinded, 4-way comparison trial. Gastrointest Endosc 2008;68(2):255–266. DOI: 10.1016/j.gie.2008.02.017
Cohen SA, Ephrath H, Lewis JD, et al. Pediatric capsule endoscopy: review of the small bowel and patency capsules. J Pediatr Gastroenterol Nutr 2012;54(3):409–413. DOI: 10.1097/MPG.0b013e31822c81fd
Whitten KE, Rogers P, Ooi CY, et al. International survey of enteral nutrition protocols used in children with Crohn's disease. J Dig Dis 2012;13(2):107–112. DOI: 10.1111/j.1751-2980.2011.00558.x
Sreedharan L, Kesavelu D, Devi A. Management of paediatric Crohn's disease using exclusive enteral nutrition in the Indian subcontinent. J Emerg Technol Innov Res 2019;6(2):318–332.
Berni RC, Terrin G, Borrelli O, et al. Short- and long-term therapeutic efficacy of nutritional therapy and corticosteroids in paediatric Crohn's disease. Dig Liver Dis 2006;38(6):381–387. DOI: 10.1016/j.dld.2005.10.005
Hyams JS, Ferry GD, Mandel FS, et al. Development and validation of a pediatric Crohn's disease activity index. J Pediatr Gastroenterol Nutr 1991;12(4):439–447.
https://gastro.cchmc.org/calculators/pcdai/ accessed on 13 Oct 2022
NICE National Institute for. Health and Care Excellence. Accessed 17th July 2022, https://www.nice.org.uk/guidance/ng129
Khan KJ, Ullman TA, Ford AC, et al. Antibiotic therapy in inflammatory bowel disease: a systematic review and meta-analysis. Am J Gastroenterol 2011;106(4):661–673. DOI: 10.1038/ajg.2011.72
Olbjorn C, Nakstad B, Smastuen MC, et al. Early anti-TNF treatment in pediatric Crohn's disease. Predictors of clinical outcome in a population-based cohort of newly diagnosed patients. Scand J Gastroenterol 2014;49(12):1425–1431. DOI: 10.3109/00365521.2014.966316
Markowitz J, Grancher K, Kohn N, et al. A multicenter trial of 6-mercaptopurine and prednisone in children with newly diagnosed Crohn's disease. Gastroenterology 2000;119(4):895–902. DOI: 10.1053/gast.2000.18144
Hyams J, Crandall W, Kugathasan S, et al. Induction and maintenance infliximab therapy for the treatment of moderate-to-severe Crohn's disease in children. Gastroenterology 2007;132(3):863–1166. DOI: 10.1053/j.gastro.2006.12.003
Amil-Dias J, Kolacek S, Turner D, et al. Surgical management of Crohn disease in children: guidelines from the Paediatric IBD Porto Group of ESPGHAN. J Pediatr Gastroenterol Nutr 2017;64(5):818–835. DOI: 10.1097/MPG.0000000000001562
Ford AC, Kane SV, Khan KJ, et al. Efficacy of 5-aminosalicylates in Crohn's disease: systematic review and meta-analysis. Am J Gastroenterol 2011;106(4):617–629. DOI: 10.1038/ajg.2011.71
Baillie CT, Smith, JA. Surgical strategies in paediatric inflammatory bowel disease. World J Gastroenterol 2015;21(20):6101–6116. DOI: 10.3748/wjg.v21.i20.6101